Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease

There is a need to identify biomarkers to predict progression and to diagnose tuberculosis (TB) disease at an early stage. Following infection with Mycobacterium tuberculosis (Mtb), only about 10% of individuals progress to TB disease, while the majority mount a protective immune response that clears the infection or controls it in the long term [1]. Those Individuals whose immune system exhibit a measurable memory response to Mtb are termed Mtb-immunoreactive. The immune profile of Mtb-immunoreactive individuals, without TB disease, reflects a more protective pattern compared to individuals with TB disease, who have failed to control Mtb growth [2].
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Review Source Type: research