'Family-based strategy for Helicobacter pylori infection screening: an efficient alternative to 'test and treat strategy

We read with utmost interest the study by Zhou et al,1 which was the first family-based investigation of Helicobacter pylori (Hp) infection in China. The authors provided valuable insights into the occurrence of familial cluster effect on Hp infection and the superiority of the ‘family-based strategy’. However, their work failed to compare the screening efficiency of various established Hp management methods, leaving us curious about whether the ‘family-based strategy’ could identify more Hp-infected participants with equal number of tests conducted as compared with the widely used ‘test and treat strategy’.2 Fortunately, the family-unit data in Zhou’s study offers the possibility for such exploration. To address this gap, we built a database consisting of over one million households, based on the infection status of households and individuals from 29 provinces reported by Zhou, in order to simulate real-world scenarios. The screening protocols were simulated in national...

Source: Gut - March 7, 2024 Category: Gastroenterology Authors: Zhang, J., Deng, Y., Liu, C., Wang, H., Ren, H., Chen, S., Chen, L., Shi, B., Zhou, L. Tags: Open access, Gut PostScript Source Type: research