Proton therapy induces a local microglial neuroimmune response

Neurocognitive sequelae are the leading cause of a reduced quality of life in paediatric and adult primary brain and central nervous system tumour patients [1]. In addition, patients with brain metastases also experience debilitating neurocognitive impairment [2]. Although radiotherapy is an integral part of the treatment of brain tumours, it is associated with the development of neurocognitive side effects due to the co-irradiation of normal brain tissue [3]. Despite the introduction of 3D conformal radiotherapy and intensity-modulated radiotherapy, preventing or minimising radiotherapy-induced neurocognitive sequelae remains a pressing need [4].

Source: Radiotherapy and Oncology - March 6, 2024 Category: Radiology Authors: Dani ëlle C. Voshart, Myrthe Klaver, Yuting Jiang, Hilmar R.J. van Weering, Fleur van Buuren-Broek, Gideon P. van der Linden, Davide Cinat, Harry H. Kiewiet, Justin Malimban, Daniel A. Vazquez-Matias, Luiza Reali Nazario, Ayla C. Scholma, Jeffrey Sewdiha Tags: Original Article Source Type: research