Syngeneic Murine Models with Distinct Immune Microenvironments Represent Subsets of Human Intrahepatic Cholangiocarcinoma

Cholangiocarcinoma (CCA) is a poorly immunogenic malignancy with limited survival. Syngeneic, immunocompetent mouse models of CCA are an essential tool to elucidate the tumor immune microenvironment (TIME), understand mechanisms of tumor immune evasion, and test novel immunotherapeutic strategies. The scope of this study was to develop and characterize immunocompetent CCA models with distinct genetic drivers, and correlate tumor genomics, immunobiology, and therapeutic response.

Source: Journal of Hepatology - March 6, 2024 Category: Gastroenterology Authors: Jennifer L. Tomlinson, Binbin Li, Jingchun Yang, Emilien Loeuillard, Hannah E. Stumpf, Hendrien Kuipers, Ryan Watkins, Danielle M. Carlson, Jessica Willhite, Daniel R. O ’Brien, Rondell P. Graham, Xin Chen, Rory L. Smoot, Haidong Dong, Gregory J. Gores, Tags: Research Article Source Type: research