Prognostic Biomarkers for Malignant Progression of Oral Epithelial Dysplasia: An Updated Systematic Review and Meta-Analysis

Oral Epithelial Dysplasia (OED) is a premalignant condition, which carries an appreciable risk of malignant progression. The current grading system for severity of OED, as defined by the World Health Organisation, is a valuable clinical tool but further work is required to improve the accuracy of predicting OED malignant progression. This systematic review aims to assess progress in prognostic biomarker discovery in OED over the past 16 years.The primary objective was to update the latest evidence on prognostic biomarkers that may predict malignant progression of OED – with strict inclusion criteria of studies with a longitudinal design and long-term follow-up data to enhance the robustness and clinical translational potential of the findings.
Source: The British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Systematic review Source Type: research