Effects of weight intervention-induced changes in pathological fat mass of patients with extreme obesity and anorexia nervosa on adipokines and visceral adipocyte functions: a prospective, comparative, observational study

CONCLUSIONS: In individuals with pathological adipocyte mass, the change in adipocytokine levels in response to weight change is not as expected. The fact that these changes are not seen in the early period of the weight intervention treatment indicates that these patients have compensatory physiological mechanisms to protect them. In addition, using VAI instead of BMI, whose reliability is increasingly questioned because it does not reflect body fat mass, can be considered an alternative. However, there may be modeling errors in the early stages of weight change and in AN and EO patients where metabolic parameters reach extreme values. Therefore, it should be tested in studies where larger patient groups are followed for a more extended period.PMID:38436178 | DOI:10.26355/eurrev_202402_35474

Source: Pharmacological Reviews - March 4, 2024 Category: Drugs & Pharmacology Authors: B F Calikoglu O Telci Caklili A Kubat Uzum B Yucel Y Tutuncu A M Kurt U Barbaros I Satman Source Type: research