Tumor-intrinsic galectin-3 suppresses melanoma metastasis
Melanoma poses a poor prognosis with high mortality rates upon metastasis. Exploring molecular mechanisms governing melanoma progression paves the way for developing novel approaches to control melanoma metastasis and ultimately enhance patient survival rates. Extracellular galectin-3 (Gal-3) has emerged as a pleiotropic promoter of melanoma metastasis, exerting varying activities depending on its interacting partner. However, whether intracellular Gal-3 promotes melanoma aggressive behavior remains unknown.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Norhan B.B. Mohammed, Lee Seng Lau, Joseph Souchak, Shi Qiu, Manmeet S. Ahluwalia, Iman Osman, Charles J. Dimitroff Tags: Original Article Source Type: research