International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

Autophagy. 2024 Mar 5. doi: 10.1080/15548627.2024.2319901. Online ahead of print.ABSTRACTMacroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.PMID:38442890 | DOI:10.1080/15548627.2024.2319901

Source: Autophagy - March 5, 2024 Category: Cytology Authors: Xin Chen Andrey S Tsvetkov Han-Ming Shen Ciro Isidoro Nicholas T Ktistakis Andreas Linkermann Werner J H Koopman Hans-Uwe Simon Lorenzo Galluzzi Shouqing Luo Daqian Xu Wei Gu Olivier Peulen Qian Cai David C Rubinsztein Jen-Tsan Chi Donna D Zhang Changfeng Source Type: research