Simultaneous diversity-oriented synthesis of benzothiazoles and related diverse analogues by iodine-catalyzed intramolecular cyclization from identical substrates

Meng Cui, Xue-Lin Wang, Mengzhou Wang, Jian-Wu Xie - Volume 77(3) Synthesis scheme showing the conversion of β-ketothioamides to various benzothiazole derivatives using iodine catalystWe have developed a facile oxidative cyclization of β-ketothioamides for the simultaneous formation of a compound library similar to natural product benzothiazole derivatives, which are important structural motifs that are prevalent in both natural and designed compounds and display interesting biological and physical properties. (Image credit: M. Cui.)
Source: Australian Journal of Chemistry - Category: Chemistry Authors: Source Type: research