Systemic Sirtuin 1 as a Potential Target to Mediate Interactions Between Body Fat and Testosterone Concentration in Master Athletes

In conclusion, master athletes have higher testosterone, T/LH ratio, and Sirt1, and lower BF and FMI in relation to untrained peers. Furthermore, Sirt1 was negatively associated with BF and positively associated with testosterone and T/LH ratio. These findings suggest that increased circulating Sirt1, possibly due to the master athlete's training regimens and lifestyle, exhibits a potential mediation effect on the interaction between endocrine function and body composition.PMID:38417433 | DOI:10.1123/japa.2023-0193

Source: Journal of Aging and Physical Activity - February 28, 2024 Category: Geriatrics Authors: Patricio Lopes de Ara újo Leite Larissa Alves Maciel Samuel da Silva Aguiar Caio Victor Sousa Rodrigo Vanerson Passos Neves Ivo Vieira de Sousa Neto Lucca Campbell Sim ões Thiago Dos Santos Rosa Herbert Gustavo Sim ões Source Type: research