Heavily Treatment-Experienced Persons Living with HIV Currently in Care in Italy: characteristics, Risk Factors, and Therapeutic Options - the ICONA Foundation Cohort study

Since the mid-1990s, improved combination antiretroviral therapy (cART) has transformed HIV into a lifelong condition [1, 2]. While cART is effective, its prolonged use may reduce the efficacy of antiretrovirals (ARVs), leading to the need for personalized regimens [3-5]. Heavily-treatment experienced (HTE) patients, are a subset of People Living with HIV (PLWH) with limited ARV options due to past exposure, incomplete adherence, and acquired resistance mutations [6,7], resulting in a higher risk of unfavorable outcomes [8].

Source: International Journal of Infectious Diseases - March 4, 2024 Category: Infectious Diseases Authors: Sergio Lo Caputo, Mariacristina Poliseno, Alessandro Tavelli, Roberta Gagliardini, Stefano Rusconi, Giuseppe Lapadula, Andrea Antinori, Daniela Francisci, Loredana Sarmati, Andrea Gori, Vincenzo Spagnuolo, Francesca Ceccherini-Silberstein, Antonella d'Arm Source Type: research