General autophagy-dependent and -independent lipophagic processes collaborate to regulate the overall level of lipophagy in yeast

In this study, we report new findings about the regulation of lipophagy by analyzing, under different culture conditions, both the engulfment of LDs into the vacuole and the degradation of LD surface proteins. We find that the degradation of LD surface proteins relies on autophagy and can occur independently of lipophagy. Furthermore, glucose restriction can trigger an ATG1-independent lipophagic process, depending on the glucose concentration in the mediums. In summary, we describe an ATG-independent lipophagic process in yeast, such that the overall level of lipophagy in cells is governed by a dynamic balance between the ATG-dependent and -independent lipophagic processes.PMID:38425021 | DOI:10.1080/15548627.2024.2325297

Source: Autophagy - March 1, 2024 Category: Cytology Authors: Na Kang Jinling Tan Sisi Yan Leiying Lin Qiang Gao Source Type: research