Timing is everything: towards classification criteria for early-stage symptomatic knee osteoarthritis

More than three decades ago, the American College of Rheumatology introduced the first widely accepted classification criteria for knee osteoarthritis (OA). These criteria provided a standardized framework for identifying OA in research settings1. Since then, OA clinical trials have recruited participants based on these criteria, but have failed to identify disease-modifying interventions, raising the possibility that the ACR criteria do not capture patients early enough for interventions to restore joint homeostasis and slow or arrest the OA disease process2,3.

Source: Osteoarthritis and Cartilage - March 2, 2024 Category: Rheumatology Authors: Armaghan Mahmoudian, Lauren K King, Jean W Liew, Qiuke Wang, C Thomas Appleton, Martin Englund, Ida K Haugen, L Stefan Lohmander, Jos Runhaar, Aleksandra Turkiewicz, Tuhina Neogi, Gillian A Hawker, on behalf of the OARSI Early-stage Symptomatic Knee Osteo Tags: Commentary Source Type: research