Biomaterials-assisted therapeutic cell production and modification in vivo

The quantity of hematopoietic stem cells (HSCs) is limited, and they are mainly stored in a special microenvironment known as the bone marrow niche1. Within this niche, HSCs maintain hematopoietic homeostasis throughout the body through self-renewal, differentiation, and proliferation. Various components of the niche, such as osteolineage cells, vascular endothelial cells, perivascular stromal cells, megakaryocytes, and the nervous system, participate in regulating HSCs2. Alongside various cells regulating HSC behavior, extracellular matrix characteristics such as matrix stiffness and concentration of bioactive factors also serve as crucial regulatory factors3,4.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research