Quassinoids from Eurycoma longifolia as Potential Dihydrofolate Reductase Inhibitors: A Computational Study

CONCLUSION: From the analysis, 6-dehydrolongilactone and eurycomalide B are among the twelve compounds that showed great potential as hit-to-lead compounds based on the docking score on DHFR, drug-likeness, and ADMET properties. These results suggest a great potential to pursue validation studies via in vitro and in vivo models.PMID:38425119 | DOI:10.2174/0113892010273336240221101506

Source: Current Pharmaceutical Biotechnology - March 1, 2024 Category: Biotechnology Authors: Nurhanan Murni Yunos Mohammad Gasem Al-Thiabat Nor Jannah Sallehudin Habibah A Wahab Source Type: research