Investigation of NK cell function against two target hematological cell line using radioactive chromium assay

In this study two hematological cell lines K562 and MDS where used and target and results showed different sensitivity to killing by NK cells separated from healthy volunteers. Results have been shown that MDS release significantly more radioactive chromium indicating higher degree of necrosis during cell culture. In addition, K562 cell line is better target for NK killing in all different E:T ratio in comparison to MDS cell line previously described. Based on this, it is suggested that K562 cells be continues used in the future as better target for investigation NK killing.PMID:38422944 | DOI:10.1016/j.apradiso.2024.111251
Source: Applied Radiation and Isotopes - Category: Radiology Authors: Source Type: research