A new analog of dihydroxybenzoic acid from Saccharopolyspora sp. KR21-0001

In this study, a collection of rare actinomycetes at Kitasato University has been screened for potential novel compound producers. Among the rare actinomycetes, Saccharopolyspora sp. KR21-0001 isolated from soil on Ōha Island, Okinawa, Japan was selected as a potential producer. The strain was cultured in 20 L of production medium in a jar fermenter and the culture broth was extracted. Further purification revealed the presence of a new compound designated KR21-0001A (1). The structure was elucidated by NMR, and the absolute stereochemistry was determined by advanced Marfey’s method. The results indicated that 1 is a new analog of dihydroxybenzoic acid. 1 has no antimicrobial activity against bacteria and fungi but showed potent antioxidant activity. Beilstein J. Org. Chem. 2024, 20, 497–503. doi:10.3762/bjoc.20.44
Source: Beilstein Journal of Organic Chemistry - Category: Chemistry Authors: Tags: antioxidant activity dihydroxybenzoic acid analog rare actinomycetes Full Research Paper Source Type: research