Precision Oncology in Pediatric Cancer Surgery

Surg Oncol Clin N Am. 2024 Apr;33(2):409-446. doi: 10.1016/j.soc.2023.12.008. Epub 2023 Dec 26.ABSTRACTPediatric precision oncology has provided a greater understanding of the wide range of molecular alterations in difficult-to-treat or rare tumors with the aims of increasing survival as well as decreasing toxicity and morbidity from current cytotoxic therapies. In this article, the authors discuss the current state of pediatric precision oncology which has increased access to novel targeted therapies while also providing a framework for clinical implementation in this unique population. The authors evaluate the targetable mutations currently under investigation-with a focus on pediatric solid tumors-and discuss the key surgical implications associated with novel targeted therapies.PMID:38401917 | DOI:10.1016/j.soc.2023.12.008
Source: The Surgical Clinics of North America - Category: Surgery Authors: Source Type: research