Anti-inflammatory Polyketides from an Endophytic Fungus Chaetomium sp. UJN-EF006 of Vaccinium bracteatum

Chem Biodivers. 2024 Feb 27:e202400002. doi: 10.1002/cbdv.202400002. Online ahead of print.ABSTRACTSeven new polyketides including three chromone derivatives (1-3) and four linear ones incorporating a tetrahydrofuran ring (4-7), along with three known compounds (8-10), were obtained from the fermentation of an endophytic fungus (Chaetomium sp. UJN-EF006) isolated from the leaves of Vaccinium bracteatum. The structures of these fungal metabolites have been elucidated by spectroscopic means including MS, NMR and electronic circular dichroism. A preliminary anti-inflammatory screening with the lipopolysaccharide (LPS) induced RAW264.7 cell model revealed moderate NO production inhibitory activity for compounds 1 and 4. In addition, the expression of three LPS-induced inflammatory factors IL-6, iNOS and COX-2 was also blocked by 1 and 4.PMID:38411310 | DOI:10.1002/cbdv.202400002

Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: Yin-Yin Wang Yin-Bo Pan Ze-Yi Wan Jun-Jiang Li Jie Bao Jun-Sheng Zhang Hua Zhang Source Type: research