Autoantibody profiles in intravenous immunoglobulin preparations: A possible cause of mistaken autoimmunity diagnosis

DISCUSSION: To the best of our knowledge, this is the first study that analyzed multiple autoantibody profiles in both pooled plasma and IVIg products and that further evaluated their potential influences on diagnosis of autoimmunity. Clinicians should keep in mind that IVIgs contain several autoantibodies and that their infusion can produce false-positive serology results. To establish an accurate diagnosis, serological tests must be carefully interpreted and clinical symptoms should be more purposefully considered if patients are receiving IVIg therapy.PMID:38400628 | DOI:10.1111/trf.17766

Source: Transfusion - February 24, 2024 Category: Hematology Authors: Tatsuki Miyamoto Yuki Fukunaga Atsushi Ogasawara Ai Munakata Katsushi Murai Source Type: research