TGF- β1 Induced SOX18 Elevation Promotes Hepatocellular Carcinoma Progression and Metastasis through Transcriptionally Upregulating PD-L1 and CXCL12

Hepatocellular carcinoma (HCC) is characterized by an immune-suppressive microenvironment, which contributes to tumor progression, metastasis and immunotherapy resistance. Identification of HCC-intrinsic factors regulating immunosuppressive microenvironment is urgently needed. Here, we aimed to elucidate the role of SYR-Related High-Mobility Group Box 18 (SOX18) in inducing immunosuppression and to validate novel combination strategies for SOX18-mediated HCC progression and metastasis.

Source: Gastroenterology - February 26, 2024 Category: Gastroenterology Authors: Jie Chen, Weibo Feng, Mengyu Sun, Wenjie Huang, Guodong Wang, Xilang Chen, Yue Yin, Xiaoping Chen, Bixiang Zhang, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia Tags: Basic and Translational - Liver Source Type: research