Human genetic errors of immunity illuminate an adaptive arsenal model of rapid defenses

Trends Immunol. 2024 Feb;45(2):113-126. doi: 10.1016/j.it.2023.12.006. Epub 2024 Jan 31.ABSTRACTNew discoveries in the field of human monogenic immune diseases highlight critical genes and pathways governing immune responses. Here, I describe how the ~500 currently defined human inborn errors of immunity help shape what I propose is an 'adaptive arsenal model of rapid defenses', emphasizing the set of immunological defenses poised for rapid responses in the natural environment. This arsenal blurs the lines between innate and adaptive immunity and is established through molecular relays between cell types, often traversing from sensors (pathogen detection) to intermediates to executioners (pathogen clearance) via soluble factors. Predictions and missing information based on the adaptive arsenal model are discussed, as are emergent and outstanding questions fundamental to advances in the field.PMID:38302340 | DOI:10.1016/j.it.2023.12.006
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Source Type: research