Monoclonal Gammopathy of Anemic Significance? Resolution of Pure Red Cell Aplasia with Daratumumab-based Therapy

A 65-year-old male with a history of giant cell arteritis developed progressive anemia with hemoglobin declining from a baseline of 14-16 g/dL to 12-13 g/dL over a year. He presented to clinic with fatigue and dyspnea on exertion. Laboratory investigation was notable for a normocytic, normochromic, hypoproliferative anemia (hemoglobin of 8.9 g/dL, mean corpuscular volume 92.1 fL, mean corpuscular hemoglobin concentration 33.3 g/dL, reticulocyte count 20,300 cells/uL), mildly increased platelets to 465  × 103/uL, and normal neutrophils.
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research