LincR-PPP2R5C Promotes Th2 Cell Differentiation Through PPP2R5C/PP2A by Forming an RNA-DNA Triplex in Allergic Asthma

CONCLUSIONS: LincR-PPP2R5C regulated PPP2R5C expression and PP2A activity by forming an RNA-DNA triplex with the PPP2R5C promoter, leading to Th2 polarization in a mouse model of acute asthma. Our data presented the first definitive evidence of lncRNAs in the regulation of Th2 cells in asthma.PMID:38262392 | PMC:PMC10823138 | DOI:10.4168/aair.2024.16.1.71

Source: Allergy, Asthma and Immunology Research - January 23, 2024 Category: Allergy & Immunology Authors: Ningfei Ji Zhongqi Chen Zhengxia Wang Wei Sun Qi Yuan Xijie Zhang Xinyu Jia Jingjing Wu Jingxian Jiang Meijuan Song Tingting Xu Yanan Liu Qiyun Ma Zhixiao Sun Yanmin Bao Mingshun Zhang Mao Huang Source Type: research