Rethinking PIDs: Why the distinction between primary and secondary immune disorders is more frequently relevant than that between inborn and acquired errors of immunity

Clinical immunologists, pediatricians, and adult specialists with various subspecializations around the world are used to classify and manage patients with immune deficiencies and immune dysregulation according to their gene defect, if available, and classifications such as the International Union of Immunological Societies (IUIS) classification of inborn errors of immunity (IEIs)1,2 and the working definitions for making a clinical diagnosis of the European Society for Immunodeficiencies.3 The tables produced by these societies bear an enormous clinical and educational value, being based both on categories of immunologic mechanisms and their genetic underpinnings and on the clinical phenotypes of IEIs (Fig 1, A).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research