Psychological stress to ovalbumin peptide-specific T-cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell

In conclusion, the functions of Tr1 cells are negatively impacted by simultaneous exposure to psychological stress and immune response. Tr1 cells' immune suppressive functions can be restored by inhibiting Rnf20, which has the translational potential for the treatment of diseases of the immune system.PMID:38366844 | DOI:10.1111/imm.13767

Source: Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Xiaoyu Liu Xuejie Xu Yun Liao Wenkai Yao Xiaorui Geng Xianhai Zeng Xizhuo Sun Aifa Tang Pingchang Yang Source Type: research