HIF-1 α regulates DcR3 to promote the development of endometriosis

Decoy receptor 3 (DcR3)/TNFRSF6B is a 33-kDa soluble factor of the tumor necrosis factor receptor (TNFR) superfamily. It operates as a decoy by neutralizing Fas-ligand (FasL), lymphotoxin-like, and competing with HSV glycoprotein D for HVEM receptor. DcR3 is elevated in serum and tumor samples of various cancers and is considered a biomarker for cancer progression [1 –3]. It also exhibits non-decoy functions through interactions with heparan sulfate proteoglycans (HSPGs) such as syndecan 2 and CD44v3 [4].
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Full length article Source Type: research