Hyaluronan deposition during COVID-19 - helpful or harmful?

Trends Mol Med. 2024 Feb 7:S1471-4914(24)00003-0. doi: 10.1016/j.molmed.2024.01.003. Online ahead of print.ABSTRACTHyaluronan (HA), an extracellular matrix polysaccharide, is increased in the lungs during COVID-19 and correlates with severity. HA acts as an immune mediator that aids cell trafficking and intracellular signaling, but its role in COVID-19 is debated. Although HA is implicated in pulmonary viral disease pathogenesis, some studies suggest a potential protective function in COVID-19.PMID:38331701 | DOI:10.1016/j.molmed.2024.01.003
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Source Type: research