A Generative and Causal Pharmacokinetic Model for Factor VIII in Hemophilia A: A Machine Learning Framework for Continuous Model Refinement

In conclusion, the proposed approach introduces interesting new possibilities for model development. In the context of rare disease, the introduction of generative models facilitates sharing of synthetic data, enabling the iterative improvement of population PK models.PMID:38372445 | DOI:10.1002/cpt.3203

Source: Clinical Pharmacology and Therapeutics - February 19, 2024 Category: Drugs & Pharmacology Authors: Alexander Janssen Louk Smalbil Frank C Bennis Marjon H Cnossen Ron A A Math ôt OPTI-CLOT study group and SYMPHONY consortium Source Type: research