Dual-isotope imaging method for Actinium-225 and Bismuth-213 using alpha imaging detector

In this study, we describe and validate a spectrum decomposition method for dual-isotope imaging of 225Ac and 213Bi using an alpha imaging detector. We implemented an experiment to demonstrate the feasibility of using the alpha imaging detector to obtain distribution images using therapeutic amounts of 225Ac. In addition, we designed and conducted a Monte Carlo simulation under realistic conditions based on the experimental results to evaluate the spectrum decomposition method for dual-isotope imaging. The alpha imaging detector exhibited a detection efficiency of 18.5% and an energy resolution of 13.4% at 5.5 MeV. In the simulation, the distributions of 225Ac and 213Bi were obtained in each region with a relative error of 5%. The results of this study confirmed the feasibility of the dual-isotope imaging method for discriminating alpha-emitters using small amounts of 225Ac.PMID:38367295 | DOI:10.1016/j.apradiso.2024.111236

Source: Applied Radiation and Isotopes - February 17, 2024 Category: Radiology Authors: Jong-Guk Kim Guna Kim Hyun Su Lee Byoungsoo Kim Il-Han Lim Kwangil Kim Kyochul Lee Source Type: research