Prognostic Impact of Bone Marrow Fibrosis and Effects of Tyrosine Kinase Inhibitors on Bone Marrow Fibrosis in Chronic Myeloid Leukemia

CONCLUSION: Although BM fibrosis seems to be a crucial complication of CML with a poor prognosis, it can be reversed via TKI treatment which may result in improved survival. It might be considered to check the BM for this complication on a regular basis during therapies to test its prognostic influence in CML patients in prospective controlled trials. Further studies focused on this issue are required to utilize BM fibrosis as a candidate prognostic factor.PMID:38342726 | DOI:10.1016/j.clml.2023.12.015

Source: Clinical Lymphoma and Myeloma - February 11, 2024 Category: Cancer & Oncology Authors: Mehmet Sezgin Pepeler Mesut T ıglıoglu Simten Dagdas Esra Ozhamamc ıoglu Unsal Han Aynur Albayrak M ürüvvet Seda Aydın G ülten Korkmaz Merve Pamukcuo ğlu Funda Ceran Murat Albayrak G ülsüm Ozet Source Type: research