Demethoxylation of curcumin enhances its inhibition on human and rat 17 β-hydroxysteroid dehydrogenase 3: QSAR structure-activity relationship and in silico docking analysis

In conclusion, curcuminoids and their metabolites possess the ability to inhibit androgen biosynthesis by directly targeting human and rat 17β-HSD3. The inhibitory strength of these compounds is influenced by their lipophilicity and ionization characteristics.PMID:38360388 | DOI:10.1016/j.fct.2024.114489

Source: Food and Chemical Toxicology - February 15, 2024 Category: Food Science Authors: Zhongyao Ji Jianmin Sang Hong Wang Miaomiao Xia Ting Hao Liping Chen Han Lu Shaowei Wang Ming Yao Linxi Li Ren-Shan Ge Source Type: research