Association of blood cell ‐based inflammatory markers with gut microbiota and cancer incidence in the Rotterdam study

To evaluate the association between gut microbiota and the immune response markers NLR, PLR, SII, and WBCs count with the subsequent risk of developing cancer in the Rotterdam study cohort (ERGO). The current study was performed on 8090 participants from the population-based Rotterdam study. A significant association was found between lymphocytes and three gut microbial taxa, namely the family Streptococcaceae, genus Streptococcus, and order Lactobacillales. By analyzing the cancer data, a significant association was observed between higher systemic immune-inflammation index (SII) levels at baseline and a higher count of lymphocytes and granulocytes with increased risk of lung cancer after adjusting for age, sex, BMI, and study cohort. However, this association was lost for SII and lymphocytes after additional adjustment for smoking. In the stratified analysis, higher count of lymphocyte and granulocytes at baseline were associated with an increased risk of lung cancer in smokers after adjusting for age, sex, BMI, and study cohort. Our study revealed a positive association between gut microbiota, higher SII levels, and higher lymphocyte and granulocyte counts, with an increased risk of developing lung cancer. AbstractThe immune response –gut microbiota interaction is implicated in various human diseases, including cancer. Identifying the link between the gut microbiota and systemic inflammatory markers and their association with cancer will be important for our understandin...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research