Regulation of myocardial glucose metabolism by YAP/TAZ signaling

J Cardiol. 2024 Jan 23:S0914-5087(24)00008-X. doi: 10.1016/j.jjcc.2024.01.002. Online ahead of print.ABSTRACTThe heart utilizes glucose and its metabolites as both energy sources and building blocks for cardiac growth and survival under both physiological and pathophysiological conditions. YAP/TAZ, transcriptional co-activators of the Hippo pathway, are key regulators of cell proliferation, survival, and metabolism in many cell types. Increasing lines of evidence suggest that the Hippo-YAP/TAZ signaling pathway is involved in the regulation of both physiological and pathophysiological processes in the heart. In particular, YAP/TAZ play a critical role in mediating aerobic glycolysis, the Warburg effect, in cardiomyocytes. Here, we summarize what is currently known about YAP/TAZ signaling in the heart by focusing on the regulation of glucose metabolism and its functional significance.PMID:38266816 | DOI:10.1016/j.jjcc.2024.01.002

Source: Journal of Cardiology - January 24, 2024 Category: Cardiology Authors: Toshihide Kashihara Junichi Sadoshima Source Type: research