Development of a [89Zr]Zr-labeled human antibody using a novel phage-displayed human scFv library

CONCLUSIONS: L111 Ab targets lung cancer cells in vitro and in vivo. [89Zr]Zr-DFO-L111 is a human antibody that will be evaluated in the first-in-human study of safety and PET imaging.PMID:38277241 | DOI:10.1158/1078-0432.CCR-23-3647

Source: Clinical Cancer Research - January 26, 2024 Category: Cancer & Oncology Authors: Abhay K Singh Calvin D Lewis Cristian A W V Boas Philipp Diebolder Prashant N Jethva Aaron Rhee Jong Hee Song Young Ah Goo Shunqiang Li Michael L Nickels Yongjian Liu Buck E Rogers Vaishali Kapoor Dennis E Hallahan Source Type: research