PIEZO1-mediated mechanosensing governs NK-cell killing efficiency and infiltration in three-dimensional matrices

In conclusion, our findings demonstrate that PIEZO1-mediated mechanosensing is crucial for NK killing functions, highlighting the role of mechanosensing in NK-cell killing efficiency under 3D physiological conditions and the influence of environmental physical cues on NK-cell functions.PMID:38279603 | DOI:10.1002/eji.202350693

Source: European Journal of Immunology - January 27, 2024 Category: Allergy & Immunology Authors: Archana K Yanamandra Jingnan Zhang Galia Montalvo Xiangda Zhou Doreen Biedenweg Renping Zhao Shulagna Sharma Markus Hoth Franziska Lautenschl äger Oliver Otto Ar ánzazu Del Campo Bin Qu Source Type: research