Spatiotemporal expression profiles of c-Mpl mRNA in the tooth germ: comparative expression dynamics of vascularization-related genes

CONCLUSION: During tooth development, several kinds of cells express c-Mpl mRNA in a spatiotemporally controlled fashion, including differentiating odontoblasts. We hypothesize that c-Mpl-expressing cells appearing in the forming dental papilla at the cap stage are odontoblast progenitor cells that migrate to the site of odontoblast differentiation. There they attract vascular endothelial cells into the forming dental papilla and lead cells toward the inner enamel epithelium layer through production of angiogenic molecules (e.g., Ang-1) during migration to the site of differentiation. C-Mpl may regulate apoptosis and/or proliferation of expressing cells in order to execute normal development of the tooth.PMID:38336176 | DOI:10.1016/j.aanat.2024.152227
Source: Annals of Anatomy - Category: Anatomy Authors: Source Type: research