Hemophagocytic lymphohistiocytosis after solid organ transplantation: A challenge for clinicians

Transpl Immunol. 2024 Feb 1;83:102007. doi: 10.1016/j.trim.2024.102007. Online ahead of print.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a rare inflammatory disorder with a high mortality rate and a wide range of symptoms. Solid organ transplantation, which provides patients with a unique immunosuppressive state, is a less common predisposing factor for HLH. HLH after solid organ transplantation (HLH-SOT) is very rare and fatal. It is hard to diagnose and treat and extremely understudied. The use of immunosuppressants makes the situation of HLH-SOT more complex. This review summarizes the existing literature on HLH after solid organ transplantation and describes its triggers and symptoms, focusing on its diagnosis and treatment. We performed a literature search of case reports, case series, letters to the editor, and clinical quizzes describing patients with HLH after solid organ transplantation (HLH-SOT). We provide recommendations on the diagnosis protocol and treatment strategy based on the existing evidence.PMID:38307154 | DOI:10.1016/j.trim.2024.102007

Source: Transplant Immunology - February 2, 2024 Category: Transplant Surgery Authors: Shanshan Xu Kang He Source Type: research