An inducible CRISPRi circuit for tunable dynamic regulation of gene expression in Saccharopolyspora erythraea

This study demonstrated the effectiveness of an inducible gene downregulation approach using CRISPRi and a cumate-inducible promoter, providing valuable insights for optimizing natural product production in actinomyces.PMID:38279045 | DOI:10.1007/s10529-023-03462-z

Source: Biotechnology Letters - January 26, 2024 Category: Biotechnology Authors: Xing Jiang Xiang Ke Xiwei Tian Ju Chu Source Type: research