Novel insights into the dependence of adsorption-desorption kinetics on particle geometry in chiral chromatography

This study has confirmed that, on both particle formats, analyte diffusion on the surface of the particle is negligible, meaning that adsorption is localized, and it has been demonstrated that adsorption-desorption kinetics is strongly dependent on particle geometry and, in particular, on the loading of chiral selector. These findings are fundamental not only to unravel novel aspects of the complex enantiorecognition mechanism but also to optimize the employment of CSPs for ultra-fast and preparative applications.PMID:38358532 | DOI:10.1007/s00216-024-05186-z

Source: Analytical and Bioanalytical Chemistry - February 15, 2024 Category: Chemistry Authors: Chiara De Luca Greta Compagnin Chiara Nosengo Giulia Mazzoccanti Francesco Gasparrini Alberto Cavazzini Martina Catani Simona Felletti Source Type: research