How intrinsically disordered proteins order plant gene silencing

Trends Genet. 2024 Jan 30:S0168-9525(23)00284-6. doi: 10.1016/j.tig.2023.12.009. Online ahead of print.ABSTRACTIntrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) possess low sequence complexity of amino acids and display non-globular tertiary structures. They can act as scaffolds, form regulatory hubs, or trigger biomolecular condensation to control diverse aspects of biology. Emerging evidence has recently implicated critical roles of IDPs and IDR-contained proteins in nuclear transcription and cytoplasmic post-transcriptional processes, among other molecular functions. We here summarize the concepts and organizing principles of IDPs. We then illustrate recent progress in understanding the roles of key IDPs in machineries that regulate transcriptional and post-transcriptional gene silencing (PTGS) in plants, aiming at highlighting new modes of action of IDPs in controlling biological processes.PMID:38296708 | DOI:10.1016/j.tig.2023.12.009
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Source Type: research