Identification of genomic regions associated with resistance to gastrointestinal parasites in an indigenous sheep by single- and multiple-locus methods

Anim Genet. 2024 Jan 10. doi: 10.1111/age.13392. Online ahead of print.ABSTRACTWe investigated the association between 157 SNPs located in 75 candidate genes involved in the immune system and proxy traits for resistance to gastrointestinal nematodes in sheep. A total of 211 lambs from eight flocks were sampled. Nematode eggs per gram were counted and classified as: (i) Strongyles, (ii) Nematodirus spp., (iii) Trichuris spp. and (iv) Marshallagia marshalli. Single- and multiple-locus models were used to test the marker-trait associations. Seven significant SNPs were identified on chromosomes OAR6, 15, 16, and 19. These findings provide insights for breeding nemarode-resistant traits in low-input production systems. General linear model, fixed and random model circulating probability unification, and Bayesian-information and linkage-disequilibrium iteratively nested keyway analyses identified a significant association between the eggs per gram of Strongyles nematodes and a specific variant of the PRLR gene.PMID:38200404 | DOI:10.1111/age.13392

Source: Animal Genetics - January 10, 2024 Category: Genetics & Stem Cells Authors: S A Rafat M Barbato R Hajializadeh Valilou G H Moghaddam A Nematollahi K Periasamy R Pichler P Ajmone Marsan Source Type: research