H3K27ac modification and transcription characteristics of adipose and muscle tissues in Chuxiang Black pig

In this study, cis-regulatory elements of muscle and adipose tissues in CX pigs were investigated using ChIP-seq and RNA sequencing. Compared with the reported cis-regulatory elements of muscle and adipose tissues, 1768 and 1012 highly activated enhancers and 433 and 275 highly activated promoters in CX muscle and adipose tissues were identified, respectively. Motif analysis showed that transcription factors, such as MEF2A and MEF2C, were core regulators of highly activated enhancers and promoters in muscle. Similarly, the transcription factors JUNB and CUX1 were identified as essential for highly activated enhancers and promoters in CX adipose tissue. These results enrich the resources for the analysis of cis-regulatory elements in the pig genome and provide new basic data for further meat quality improvement through breeding in pigs.PMID:38296601 | DOI:10.1111/age.13400

Source: Animal Genetics - January 31, 2024 Category: Genetics & Stem Cells Authors: Renzhuo Kuang Zhixiang Xu Honghong Zhou Zhao Zhang Hao Peng Daoyuan Wang Xuewen Xu Shuhong Zhao Yunxia Zhao Mengjin Zhu Source Type: research