Early regional changes in retina and choroid of chicks following monocular hemifield form deprivation

Exp Eye Res. 2024 Jan 9;239:109786. doi: 10.1016/j.exer.2024.109786. Online ahead of print.ABSTRACTTo investigate regional changes in the chick retina and choroid after hemifield form deprivation (HFD). Ten chicks were randomly and equally divided into a temporal retinal deprivation (TRD) and nasal retinal deprivation (NRD) group. HFD was induced with half-lateral translucent plastic goggles in the right eye; the left eye was kept untreated. Swept-source optical coherence tomography (SS-OCT) images obtained at 0, 3, and 72 hours (h) were analyzed using customized software. After 72 h of TRD, the retinal thickness (RT) of the treated eyes was significantly less than that of the fellow eyes in the temporal (P = 0.034) rather than the nasal (P = 0.083) region. In the NRD group, the RT of the treated eyes was thinner in both the nasal and temporal regions than that of the fellow eyes (P < 0.01). The RT alterations were more pronounced in the temporal (Δ = -16.86 ± 7.14 μm) than in the nasal (Δ = -13.44 ± 4.83 μm) region after 72-h TRD (P = 0.036), whereas the opposite was observed in the NRD group (P = 0.008). The choroidal thickness (ChT) of the treated eyes was less in both the nasal and temporal regions than that of the fellow eyes in both groups after 72-h treatment (P < 0.01). The ChT alterations were more pronounced in the temporal (Δ = -2.48 ± 8.95 μm) than in the nasal (Δ = 23.65 ± 13.58 μm) region after 72-h TRD (P = 0.021), whereas the NRD group showed...

Source: Experimental Eye Research - January 11, 2024 Category: Opthalmology Authors: Xiaoliao Peng Yangyi Huang Yuliang Wang Jianmin Shang Yang Shen Zhi Chen Xingtao Zhou Tian Han Source Type: research