Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis

Shi et  al. identify a dual regulation of the putative mitochondrial glutathione transporter SLC25A39 by mitochondrial protease AFG3L2 and iron sensing, which enables an autoregulatory mechanism orchestrating glutathione and iron metabolism in mitochondria.

Source: Molecular Cell - December 28, 2023 Category: Cytology Authors: Xiaojian Shi, Marisa DeCiucis, Kariona A. Grabinska, Jean Kanyo, Adam Liu, Tukiet T. Lam, Hongying Shen Tags: Short article Source Type: research