EXO1 protects BRCA1-deficient cells against toxic DNA lesions

van de Kooij et  al. identify loss of the exonuclease EXO1 as a vulnerability of BRCA1-deficient cells. Mechanistically, cells deficient for both BRCA1 and EXO1 suffer from unrepaired DNA double-stranded breaks due to the loss of two break repair pathways, homologous recombination, and single-strand annealing.

Source: Molecular Cell - January 23, 2024 Category: Cytology Authors: Bert van de Kooij, Anne Schreuder, Raphael Pavani, Veronica Garzero, Sidrit Uruci, Tiemen J. Wendel, Arne van Hoeck, Marta San Martin Alonso, Marieke Everts, Dana Koerse, Elsa Callen, Jasper Boom, Hailiang Mei, Edwin Cuppen, Martijn S. Luijsterburg, Marce Tags: Article Source Type: research