GSK3 β/NF-κB dependent transcriptional regulation of homeostatic hepatocyte < em > Tnf < /em > production

CONCLUSION: These results demonstrate that GSK3β and NF-κB are essential for mediating Tnf expression and constitutive hepatocyte cell growth. These findings add to a growing body of literature on TNFα mediated hepatocyte homeostasis and identify novel molecular mechanisms involved in mediating response to various disease states in the liver.PMID:38193163 | DOI:10.1152/ajpgi.00229.2023

Source: Am J Physiol Gastroi... - January 9, 2024 Category: Gastroenterology Authors: Maya R Grayck William C McCarthy Mack Solar Emma Golden Natarajan Balasubramaniyan Lijun Zheng Laura G Sherlock Clyde J Wright Source Type: research