Prognostic impact of CEBPA mutational subgroups in adult AML

In conclusion, these results demonstrate bZIPInDel mutations to be the major independent determinant of outcome in CEBPA-mutant AML, thereby refining current classifications according to WHO (including all dmCEBPA and smCEBPA bZIP) as well as ELN2022 and ICC recommendations (including CEBPA bZIPms).PMID:38228680 | PMC:PMC10844079 | DOI:10.1038/s41375-024-02140-x

Source: Hamostaseologie - January 16, 2024 Category: Hematology Authors: Julia-Annabell Georgi Sebastian Stasik Michael Kramer Manja Meggendorfer Christoph R öllig Torsten Haferlach Peter Valk David Linch Tobias Herold Nicolas Duployez Franziska Taube Jan Moritz Middeke Uwe Platzbecker Hubert Serve Claudia D Baldus Carsten Mu Source Type: research