Reply to comments by Dr. Ali Shayanfar

Eur J Pharm Biopharm. 2024 Feb 12:114216. doi: 10.1016/j.ejpb.2024.114216. Online ahead of print.ABSTRACTSeveral clarifications are made pertaining to the study on the cocrystallization of 5-fluorouracil (5-FU) and gallic acid (GA). Dr. Shayanfar's perspective in the solubility and biological activity of cocrystals is recognized, and his insightful guidance on solubility determination methodologies is greatly appreciated. A misconception concerning the cytotoxicity assay methodology in the Shayanfar's comments is addressed. Furthermore, the stability of the 5-FU-GA cocrystal during solubility measurement is highlighted, as evidenced by XRD analysis of residual solids. Lastly, the independence of the elevated cytotoxicity of the cocrystal from 5-FU solubility is deliberated, aligning with preceding research outcomes.PMID:38355022 | DOI:10.1016/j.ejpb.2024.114216
Source: European Journal of Pharmaceutics and Biopharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research