Recent discoveries of the role of histone modifications and related inhibitors in pathological cardiac hypertrophy

Drug Discov Today. 2024 Feb;29(2):103878. doi: 10.1016/j.drudis.2024.103878. Epub 2024 Jan 10.ABSTRACTPathological cardiac hypertrophy is a common response of the heart to various pathological stimuli. In recent years, various histone modifications, including acetylation, methylation, phosphorylation and ubiquitination, have been identified to have crucial roles in regulating chromatin remodeling and cardiac hypertrophy. Novel drugs targeting these epigenetic changes have emerged as potential treatments for pathological cardiac hypertrophy. In this review, we provide a comprehensive summary of the roles of histone modifications in regulating the development of pathological cardiac hypertrophy, and discuss potential therapeutic targets that could be utilized for its treatment.PMID:38211819 | DOI:10.1016/j.drudis.2024.103878
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Source Type: research